Synergic stimulation of serotonin 5-HT<sub>1A</sub> receptor and &#945;<sub>2</sub>-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives.

Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Micheli, Laura; Del Bello, Fabio; Giannella, Mario; Piergentili, Alessandro; Pigini, Maria; Quaglia, Wilma

Synergic stimulation of serotonin 5-HT_1A receptor and α₂-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives.

Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Micheli, Laura; Del Bello, Fabio; Giannella, Mario; Piergentili, Alessandro; Pigini, Maria; Quaglia, Wilma.

Afiliação

Di Cesare Mannelli L; Department of Neuroscience, Psychology, Drug Research and Child Health - Neurofarba - Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50039 Firenze, Italy. Electronic address: lorenzo.mannelli@unifi.it.
Ghelardini C; Department of Neuroscience, Psychology, Drug Research and Child Health - Neurofarba - Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50039 Firenze, Italy.
Micheli L; Department of Neuroscience, Psychology, Drug Research and Child Health - Neurofarba - Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50039 Firenze, Italy.
Del Bello F; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Giannella M; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Piergentili A; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Pigini M; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Quaglia W; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.

Eur J Pharmacol ; 810: 128-133, 2017 Sep 05.

Article em En | MEDLINE | ID: mdl-28633926

Assuntos

Imidazolinas/química; Imidazolinas/farmacologia; Neuralgia/tratamento farmacológico; Receptor 5-HT1A de Serotonina/metabolismo; Receptores Adrenérgicos alfa 2/metabolismo; Animais; Desenho de Fármacos; Sinergismo Farmacológico; Imidazolinas/uso terapêutico; Masculino; Neuralgia/metabolismo; Ratos; Ratos Sprague-Dawley; Relação Estrutura-Atividade

Palavras-chave

(S)-(-)-1 (PubChem CID 10333157); 2 (PubChem CID 11265631); 3 (PubChem CID 11211035); 4 (PubChem CID 44549156); 5 (PubChem CID 23622576); CCI; Chronic pain; Gabapentin; Imidazoline; Mixed 5HT(1A)/α(2)agonists; Neuropathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos alfa 2 / Receptor 5-HT1A de Serotonina / Imidazolinas / Neuralgia Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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