The TORC that Gets the GC Cycling.

Deenick, Elissa K; Tangye, Stuart G

Deenick, Elissa K; Tangye, Stuart G.

Afiliação

Deenick EK; Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW, Australia. Electronic address: e.deenick@garvan.org.au.
Tangye SG; Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW, Australia.

Immunity ; 46(6): 974-976, 2017 06 20.

Article em En | MEDLINE | ID: mdl-28636966

ABSTRACT

ABSTRACT

The signaling pathways regulating positive selection in germinal centers (GCs) are incompletely understood. Ersching et al. (2017) identify a critical but temporal role for the action of the kinase mechanistic target of rapamycin complex (mTORC1), which promotes key changes in GC B cells and thereby facilitates affinity maturation.

Assuntos

Linfócitos B; Centro Germinativo; Humanos; Transdução de Sinais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Centro Germinativo Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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