Functional characterization of 21 allelic variants of dihydropyrimidinase.

Hishinuma, Eiji; Akai, Fumika; Narita, Yoko; Maekawa, Masamitsu; Yamaguchi, Hiroaki; Mano, Nariyasu; Oda, Akifumi; Hirasawa, Noriyasu; Hiratsuka, Masahiro

Hishinuma, Eiji; Akai, Fumika; Narita, Yoko; Maekawa, Masamitsu; Yamaguchi, Hiroaki; Mano, Nariyasu; Oda, Akifumi; Hirasawa, Noriyasu; Hiratsuka, Masahiro.

Afiliação

Hishinuma E; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Akai F; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Narita Y; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Maekawa M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Yamaguchi H; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Mano N; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Oda A; Department of Biophysical Chemistry, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan.
Hirasawa N; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Hiratsuka M; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sen

Biochem Pharmacol ; 143: 118-128, 2017 11 01.

Article em En | MEDLINE | ID: mdl-28642038

Assuntos

Amidoidrolases; Antineoplásicos/metabolismo; Fluoruracila/análogos & derivados; Variação Genética; Uracila/análogos & derivados; Alelos; Amidoidrolases/genética; Amidoidrolases/metabolismo; Linhagem Celular; Relação Dose-Resposta a Droga; Fluoruracila/metabolismo; Humanos; Modelos Moleculares; Estabilidade Proteica; Especificidade por Substrato; Transfecção; Uracila/metabolismo

Palavras-chave

5-Fluorouracil (PubChem CID: 3385); Bortezomib (PubChem CID: 387447); Cycloheximide (PubChem CID: 6197); DPYS; Dihydro-5-fluorouracil (PubChem CID: 121997); Dihydropyrimidinase; Dihydrothymine (PubChem CID: 93556); Dihydrouracil (PubChem CID: 649); Dithiothreitol (PubChem CID: 19001); Drug metabolism; Fluoro-ß-ureidopropionic acid (PubChem CID: 151244); Fluoropyrimidine; Genetic polymorphism; ß-Ureidopropionic acid (PubChem CID: 111)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Uracila / Variação Genética / Fluoruracila / Amidoidrolases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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