Effects of cocoa-enriched diet on orofacial pain in a murine model.
Orthod Craniofac Res
; 20 Suppl 1: 157-161, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28643911
ABSTRACT
OBJECTIVES:
To investigate and discuss the effects of cocoa on orofacial pain. SETTING AND SAMPLE POPULATION The Department of Orthodontics at the University of Florida (UF). Male and female hairless rats (N=20/group) were tested. MATERIALS ANDMETHODS:
Rats were tested using the Orofacial Pain Assessment Device (OPAD) before and after changing their food from the standard chow to a cocoa-enriched or control-equivalent diet.RESULTS:
Male rats fed the cocoa diet had a significantly higher operant pain index when tested at 37°C as compared to control diet-fed animals. Female rats on the cocoa diet had a significantly higher pain index when tested at 18°C and 44°C, as compared to animals fed the control diet. Capsaicin-induced pain was inhibited, with cocoa-diet male rats having a significantly higher pain index than control-diet male rats and cocoa-diet female rats at both 37°C and 44°C. Cocoa-diet female rats had a significantly higher pain index at 44°C than control-diet females. Mechanical sensitivity was affected following capsaicin cream, with a significantly decreased tolerated bottle distance in both cocoa- and control-diet animals, but there was no difference between cocoa- and control-diet groups.CONCLUSION:
Using the OPAD operant system, we demonstrated that a diet rich in cocoa was effective in inhibiting neurogenic inflammatory pain in rats. This has implications for the use of novel alternative therapies such as diet modification for pain control.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Facial
/
Cacau
/
Dieta
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article