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Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments.
Kwakwa, Kristin A; Vanderburgh, Joseph P; Guelcher, Scott A; Sterling, Julie A.
Afiliação
  • Kwakwa KA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.
  • Vanderburgh JP; Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, 2215B Garland Ave, 1235 MRBIV, Nashville, TN, 37232, USA.
  • Guelcher SA; Department of Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA.
  • Sterling JA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.
Curr Osteoporos Rep ; 15(4): 247-254, 2017 08.
Article em En | MEDLINE | ID: mdl-28646444
ABSTRACT
PURPOSE OF REVIEW Bone is a structurally unique microenvironment that presents many challenges for the development of 3D models for studying bone physiology and diseases, including cancer. As researchers continue to investigate the interactions within the bone microenvironment, the development of 3D models of bone has become critical. RECENT

FINDINGS:

3D models have been developed that replicate some properties of bone, but have not fully reproduced the complex structural and cellular composition of the bone microenvironment. This review will discuss 3D models including polyurethane, silk, and collagen scaffolds that have been developed to study tumor-induced bone disease. In addition, we discuss 3D printing techniques used to better replicate the structure of bone. 3D models that better replicate the bone microenvironment will help researchers better understand the dynamic interactions between tumors and the bone microenvironment, ultimately leading to better models for testing therapeutics and predicting patient outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osso e Ossos / Neoplasias Ósseas / Microambiente Tumoral / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osso e Ossos / Neoplasias Ósseas / Microambiente Tumoral / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article