Redox-Based Regulation of Bacterial Development and Behavior.
Annu Rev Biochem
; 86: 777-797, 2017 06 20.
Article
em En
| MEDLINE
| ID: mdl-28654321
ABSTRACT
Severe changes in the environmental redox potential, and resulting alterations in the oxidation states of intracellular metabolites and enzymes, have historically been considered negative stressors, requiring responses that are strictly defensive. However, recent work in diverse organisms has revealed that more subtle changes in the intracellular redox state can act as signals, eliciting responses with benefits beyond defense and detoxification. Changes in redox state have been shown to influence or trigger chromosome segregation, sporulation, aerotaxis, and social behaviors, including luminescence as well as biofilm establishment and dispersal. Connections between redox state and complex behavior allow bacteria to link developmental choices with metabolic state and coordinate appropriate responses. Promising future directions for this area of study include metabolomic analysis of species- and condition-dependent changes in metabolite oxidation states and elucidation of the mechanisms whereby the redox state influences circadian regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
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Esporos Bacterianos
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Regulação Bacteriana da Expressão Gênica
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Proteínas Serina-Treonina Quinases
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Biofilmes
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Proteínas de Escherichia coli
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article