Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the &#945;-ketoacid-hydroxylamine (KAHA) ligation.

Murar, Claudia E; Harmand, Thibault J; Bode, Jeffrey W

Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the α-ketoacid-hydroxylamine (KAHA) ligation.

Murar, Claudia E; Harmand, Thibault J; Bode, Jeffrey W.

Afiliação

Murar CE; Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH-Zürich, CH-8093 Zürich, Switzerland.
Harmand TJ; Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH-Zürich, CH-8093 Zürich, Switzerland.
Bode JW; Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH-Zürich, CH-8093 Zürich, Switzerland; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya 464-8602, Japan. Electronic address: bode@org.chem.ethz.ch.

Bioorg Med Chem ; 25(18): 4996-5001, 2017 09 15.

Article em En | MEDLINE | ID: mdl-28662960

Assuntos

Hidroxilaminas/química; Prolina/análogos & derivados; Proteínas/síntese química; Aldeídos/química; Espectroscopia de Ressonância Magnética; Prolina/síntese química; Prolina/química; Proteínas/química; Estereoisomerismo

Palavras-chave

(S)-N-Boc-5-oxaproline; Chemical ligation; Chemical protein synthesis; KAHA ligation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prolina / Proteínas / Hidroxilaminas Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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