Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus.
Neurosci Lett
; 655: 151-155, 2017 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-28668380
ABSTRACT
A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Privação do Sono
/
Serotonina
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Receptor 5-HT1A de Serotonina
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Região CA1 Hipocampal
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article