Biophysical regulation of early limb bud morphogenesis.
Dev Biol
; 429(2): 429-433, 2017 09 15.
Article
em En
| MEDLINE
| ID: mdl-28669818
ABSTRACT
The physical basis of morphogenesis is a fascinating concern that has been a longstanding interest of developmental biologists. In this review, I attempt to incorporate earlier and recent biophysical concepts and data to explain basic features of early limb bud morphogenesis. In particular, I discuss the influence of mesenchymal cohesion and physical properties that might contribute to phase separation of the bud from the lateral plate, the possibility that the early dorsoventral limb bud axis is moulded by the surface ectoderm, and endogenous electric fields that might contribute to oriented cell movements which generate the early limb bud. A combination of quantitative biophysical experimentation and modelling will likely advance this field.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Botões de Extremidades
/
Fenômenos Biofísicos
/
Morfogênese
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article