Benzyl isothiocyanate (BITC) induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells via activation of caspase-8/Bid and the reactive oxygen species-dependent mitochondrial pathway.

Shang, Hung-Sheng; Shih, Yung-Luen; Lu, Tai-Jung; Lee, Ching-Hsiao; Hsueh, Shu-Ching; Chou, Yu-Cheng; Lu, Hsu-Feng; Liao, Nien-Chieh; Chung, Jing-Gung

Shang, Hung-Sheng; Shih, Yung-Luen; Lu, Tai-Jung; Lee, Ching-Hsiao; Hsueh, Shu-Ching; Chou, Yu-Cheng; Lu, Hsu-Feng; Liao, Nien-Chieh; Chung, Jing-Gung.

Afiliação

Shang HS; Department of Pathology, Division of Clinical Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Shih YL; Department of School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, Republic of China.
Lu TJ; Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Republic of China.
Lee CH; School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan, Republic of China.
Hsueh SC; Jen-The Junior College of Medicine, Nursing and Management, Miaoli County, Taiwan, Republic of China.
Chou YC; Jen-The Junior College of Medicine, Nursing and Management, Miaoli County, Taiwan, Republic of China.
Lu HF; Department of Clinical Pathology, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China.
Liao NC; Division of Neurosurgical Oncology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China.
Chung JG; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, Republic of China.

Environ Toxicol ; 31(12): 1751-1760, 2016 Dec.

Article em En | MEDLINE | ID: mdl-28675694

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Neoplasias Encefálicas/tratamento farmacológico; Caspase 8/metabolismo; Glioblastoma/tratamento farmacológico; Isotiocianatos/farmacologia; Mitocôndrias/metabolismo; Caspase 3/metabolismo; Caspase 9/metabolismo; Inibidores de Caspase/farmacologia; Linhagem Celular Tumoral; Ativação Enzimática; Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

BITC; GBM 8401 human brain glioblastoma multiforms cells; apoptosis; mitochondria

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Apoptose / Isotiocianatos / Glioblastoma / Caspase 8 / Mitocôndrias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google