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Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.
Haas, Laura T; Salazar, Santiago V; Smith, Levi M; Zhao, Helen R; Cox, Timothy O; Herber, Charlotte S; Degnan, Andrew P; Balakrishnan, Anand; Macor, John E; Albright, Charles F; Strittmatter, Stephen M.
Afiliação
  • Haas LT; Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT 06520, USA; Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, 72074 Tübingen, Germany.
  • Salazar SV; Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Smith LM; Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Zhao HR; Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Cox TO; Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Herber CS; Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Degnan AP; Bristol-Myers Squibb Research and Development, Wallingford, CT 06492, USA.
  • Balakrishnan A; Bristol-Myers Squibb Research and Development, Wallingford, CT 06492, USA.
  • Macor JE; Bristol-Myers Squibb Research and Development, Wallingford, CT 06492, USA.
  • Albright CF; Bristol-Myers Squibb Research and Development, Wallingford, CT 06492, USA.
  • Strittmatter SM; Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT 06520, USA; Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: stephen.strittmatter@yale.edu.
Cell Rep ; 20(1): 76-88, 2017 07 05.
Article em En | MEDLINE | ID: mdl-28683325
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transmissão Sináptica / Fármacos Neuroprotetores / Doença de Alzheimer / Receptor de Glutamato Metabotrópico 5 Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transmissão Sináptica / Fármacos Neuroprotetores / Doença de Alzheimer / Receptor de Glutamato Metabotrópico 5 Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article