Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography.
Ocul Immunol Inflamm
; 27(2): 235-243, 2019.
Article
em En
| MEDLINE
| ID: mdl-28700251
ABSTRACT
PURPOSE:
To assess structural changes in retina and choroid after systemic corticosteroid therapy in Vogt-Koyanagi-Harada (VKH) disease using swept-source optical coherence tomography (SS-OCT).METHODS:
SS-OCT was conducted before treatment and during first-month follow-up in 16 eyes treated with systemic corticosteroids for active VKH. Retina was divided into five zones depending on pretreatment choroidal thickness (CT) of <100, >100 to <200, >200 to <300, >300 to <400 and >400µm, and changes in retinal thickness and CT after treatment in these zones were compared with baseline.RESULTS:
Mean CT significantly improved from 83.1±8.75 to 156.4±62.73µm(p = 0.008) in the zone with pre-CT <100µm and significantly decreased from 336.1 ± 17.28 to 266.28 ± 81.39µm(p = 0.008) in the zone with pre-CT > 300µm.CONCLUSIONS:
We have shown choroidal remodeling in VKH. SS-OCT can serve as an important noninvasive tool in assessment of treatment response in patients with VKH disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
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Metilprednisolona
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Acuidade Visual
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Síndrome Uveomeningoencefálica
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Corioide
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Tomografia de Coerência Óptica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article