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Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation.
Youn, Hye Sook; Kim, Tae-Yoon; Park, Ui-Hyun; Moon, Seung-Tae; An, So-Jung; Lee, Yong-Kyu; Hwang, Jin-Taek; Kim, Eun-Joo; Um, Soo-Jong.
Afiliação
  • Youn HS; Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Korea.
  • Kim TY; Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Korea.
  • Park UH; Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Korea.
  • Moon ST; Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Korea.
  • An SJ; Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Korea.
  • Lee YK; Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Korea.
  • Hwang JT; Korea Food Research Institute, Bundang-gu, Seongnam-si, 463-746, Korea.
  • Kim EJ; Department of Molecular Biology, Dankook University, Gyeonggi-do, 448-701, Korea.
  • Um SJ; Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Korea. umsj@sejong.ac.kr.
Sci Rep ; 7(1): 5198, 2017 07 12.
Article em En | MEDLINE | ID: mdl-28701722
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Senescência Celular / Embrião de Mamíferos / Proteínas Proto-Oncogênicas c-akt / Fatores de Transcrição E2F / Fibroblastos / Proteína Potenciadora do Homólogo 2 de Zeste Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Senescência Celular / Embrião de Mamíferos / Proteínas Proto-Oncogênicas c-akt / Fatores de Transcrição E2F / Fibroblastos / Proteína Potenciadora do Homólogo 2 de Zeste Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article