Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling.

Bauters, Dries; Cobbaut, Mathias; Geys, Lotte; Van Lint, Johan; Hemmeryckx, Bianca; Lijnen, H Roger

Bauters, Dries; Cobbaut, Mathias; Geys, Lotte; Van Lint, Johan; Hemmeryckx, Bianca; Lijnen, H Roger.

Afiliação

Bauters D; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, B-3000 Leuven, Belgium.
Cobbaut M; Department of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, KU Leuven, B-3000 Leuven, Belgium.
Geys L; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, B-3000 Leuven, Belgium.
Van Lint J; Department of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, KU Leuven, B-3000 Leuven, Belgium.
Hemmeryckx B; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, B-3000 Leuven, Belgium.
Lijnen HR; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, B-3000 Leuven, Belgium.

Mol Metab ; 6(7): 715-724, 2017 07.

Article em En | MEDLINE | ID: mdl-28702327

Assuntos

Proteína ADAMTS5/genética; Tecido Adiposo Marrom/metabolismo; Tecido Adiposo Branco/metabolismo; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo; Proteína ADAMTS5/deficiência; Proteína ADAMTS5/metabolismo; Tecido Adiposo Branco/efeitos dos fármacos; Agonistas de Receptores Adrenérgicos beta 3/farmacologia; Animais; Células Cultivadas; Dioxóis/farmacologia; Metabolismo Energético; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Termogênese

Palavras-chave

%ID/g, percentage injected dose per gram; ADAMTS, A disintesgrin and metalloproteinase with a thrombospondin type-1 motif; ADAMTS5; AT, adipose tissue; BAT, brown adipose tissue; Beige; Brown adipose tissue; Browning; CREB, cAMP responsive element-binding protein; ECM, extracellular matrix; GON, gonadal; HFD, high-fat diet; Obesity; SC, subcutaneous; SUV, standardized uptake value; TLG, total lesion glycolysis; Thermogenesis; UCP1, uncoupling protein 1; WAT, white adipose tissue; ß3-AR, beta-3 adrenergic receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico / Tecido Adiposo Branco / Proteína ADAMTS5 Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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