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Peto's Paradox: how has evolution solved the problem of cancer prevention?
Tollis, Marc; Boddy, Amy M; Maley, Carlo C.
Afiliação
  • Tollis M; Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, 727 E. Tyler St., Tempe, AZ, 85287-5001, USA.
  • Boddy AM; Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, 727 E. Tyler St., Tempe, AZ, 85287-5001, USA.
  • Maley CC; Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, 727 E. Tyler St., Tempe, AZ, 85287-5001, USA. maley@asu.edu.
BMC Biol ; 15(1): 60, 2017 07 13.
Article em En | MEDLINE | ID: mdl-28705195
The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto's Paradox. We discuss what is known about Peto's Paradox and provide hints of what is yet to be discovered.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamanho Corporal / Evolução Biológica / Longevidade / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamanho Corporal / Evolução Biológica / Longevidade / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article