The collaborative work of droplet assembly.

ABSTRACT

Three proteins have been implicated in the assembly of cytoplasmic lipid droplets seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.