Relative exchangeable copper: A valuable tool for the diagnosis of Wilson disease.
Liver Int
; 38(2): 350-357, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-28719006
ABSTRACT
BACKGROUND & AIMS:
Measuring of the relative exchangeable copper seems to be a promising tool for the diagnosis of Wilson disease. The aim of our study is to determine the performance of REC for the diagnosis of Wilson disease in a population of patients with chronic liver diseases.METHODS:
Measuring of exchangeable serum copper levels and relative exchangeable copper was performed in a group of Wilson disease patients at diagnosis or at clinical deterioration because of non-compliance (group 1, n=9), a group of stable WD patients (group 2, n=40), and two groups of patients (adult and paediatric) followed for non-Wilsonian liver diseases (group 3, n=103 and group 4, n=49 respectively).RESULTS:
Exchangeable serum copper (N 0.6-1.1 µmol/L) was significantly higher in group 1 (mean 2.2±0.7 µmol/L) compared to the other three groups group 2=0.9±0.4 µmol/L, group 3=1.2±0.4 µmol/L, group 4=1.1±0.3 µmol/L (P<0.05). Relative exchangeable copper was significantly higher in Wilson disease patients group 1 and 2 (mean 52.6% and 43.8%) compared to patients suffering from other liver diseases (mean 7.1% and 5.9%) (P<0.05).CONCLUSIONS:
Our study confirms that the determination of relative exchangeable copper is a highly valuable tool for the diagnosis of Wilson disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Degeneração Hepatolenticular
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article