Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.
PLoS One
; 12(7): e0181454, 2017.
Article
em En
| MEDLINE
| ID: mdl-28719654
ABSTRACT
Vibrio vulnificus (V. vulnificus), a Gram-negative marine bacterium, can cause life-threatening primary septicemia, especially in patients with liver diseases. How V. vulnificus affects the liver and how it acts on macrophages are not well understood. In this report, we demonstrated that V. vulnificus infection causes a strong inflammatory response, marked expansion of liver-resident macrophages, and liver damage in mice. We demonstrated further that V. vulnificus activates mTOR in macrophages and inhibition of mTOR differentially regulates V. vulnificus induced inflammatory responses, suggesting the possibility of targeting mTOR as a strategy to modulate V. vulnificus induced inflammatory responses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vibrio vulnificus
/
Serina-Treonina Quinases TOR
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article