Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling.
Sci Rep
; 7(1): 5814, 2017 07 19.
Article
em En
| MEDLINE
| ID: mdl-28724955
ABSTRACT
Currently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV infection therapy. Lectins from mushroom are natural and active proteins which have been shown important biological functions. However, little is known about the immunological mechanism engaged by mushroom lectins. Here we report that, lectin from Pleurotus ostreatus (POL) stimulated innate response by activating Toll-like receptor 6 signal pathway of dendritic cells. Subsequently POL enhanced HBV specific antibody level and follicular helper T cells response which overcame HBV tolerance in transgenic mice. This study suggests a novel mechanism for POL acting on immune response and a therapeutic approach to break HBV tolerance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Vírus da Hepatite B
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Agaricales
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Receptor 6 Toll-Like
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Tolerância Imunológica
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Lectinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article