Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic Î³-aminobutyric acid receptors.

Lebedev, D S; Ivanov, I A; Kryukova, E V; Starkov, V G; Tsetlin, V I; Utkin, Yu N

Lebedev, D S; Ivanov, I A; Kryukova, E V; Starkov, V G; Tsetlin, V I; Utkin, Yu N.

Afiliação

Lebedev DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. dmitry-1@bk.ru.
Ivanov IA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
Kryukova EV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
Starkov VG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
Tsetlin VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
Utkin YN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.

Dokl Biochem Biophys ; 474(1): 178-182, 2017 May.

Article em En | MEDLINE | ID: mdl-28726106

ABSTRACT

ABSTRACT

Compounds activating Î³-aminobutyric acid type A receptor were isolated from the toad Bufo bufo venom as a result of chromatographic separation. Analysis of the structure of these compounds by mass spectrometry and nuclear magnetic resonance showed that they are arginine derivatives of dicarboxylic acids and represent suberylarginine, pimeloylarginine, and adipoylarginine.

Assuntos

Arginina/química; Bufo bufo; Ácidos Dicarboxílicos/química; Ácidos Dicarboxílicos/farmacologia; Agonistas de Receptores de GABA-A/química; Agonistas de Receptores de GABA-A/farmacologia; Glândula Parótida/metabolismo; Receptores de GABA-A/metabolismo; Animais; Ácidos Dicarboxílicos/metabolismo; Agonistas de Receptores de GABA-A/metabolismo; Células HEK293; Humanos; Ligantes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândula Parótida / Arginina / Bufo bufo / Receptores de GABA-A / Ácidos Dicarboxílicos / Agonistas de Receptores de GABA-A Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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