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Lipid-lowering therapy of everolimus-related severe hypertriglyceridaemia in a pancreatic neuroendocrine tumour (pNET).
De Gennaro Colonna, V; Pavanello, C; Rusconi, F; Sartore-Bianchi, A; Siena, S; Castelnuovo, S; Sirtori, C R; Mombelli, G.
Afiliação
  • De Gennaro Colonna V; Department of Clinical Sciences and Community Health, University of Milano, Milano, Italy.
  • Pavanello C; Dyslipidemia Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Rusconi F; Department of Pharmacological and Biomolecular Sciences and, University of Milano, Milano, Italy.
  • Sartore-Bianchi A; Department of Hematology and Oncology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Siena S; Department of Hematology and Oncology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Castelnuovo S; Department of Hematology and Oncology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Sirtori CR; Department of Oncology and Hematology, University of Milano, Milano, Italy.
  • Mombelli G; Dyslipidemia Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
J Clin Pharm Ther ; 43(1): 114-116, 2018 Feb.
Article em En | MEDLINE | ID: mdl-28730672
ABSTRACT
WHAT IS KNOWN AND

OBJECTIVE:

Hypertriglyceridaemia (HTG) is a potentially serious side effect of everolimus therapy. We here report a case of severe HTG in an everolimus-treated patient and provide recommendations for its management. CASE

SUMMARY:

The patient was a 70-year-old woman, being treated with everolimus for a pancreatic neuroendocrine tumour (pNET). She developed severe HTG to a maximum of 969 mg/dL after 22 months of therapy. Treatment with fenofibrate rapidly normalized triglyceride (TG) levels. WHAT IS NEW AND

CONCLUSION:

Severe HTG may occur in everolimus-treated patients. Prescription of the appropriate therapy can allow patients to continue this medication.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertrigliceridemia / Tumores Neuroendócrinos / Everolimo / Antineoplásicos Tipo de estudo: Guideline Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertrigliceridemia / Tumores Neuroendócrinos / Everolimo / Antineoplásicos Tipo de estudo: Guideline Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article