Evidence of Heritable Determinants of Decompression Sickness in Rats.
Med Sci Sports Exerc
; 49(12): 2433-2438, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28731987
ABSTRACT
INTRODUCTION:
Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation after a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the interindividual variability of DCS occurrence. This study aimed to experimentally assess the existence of heritable factors involved in DCS occurrence by selectively breeding individuals resistant to DCS from a population stock of Wistar rats.METHODS:
Fifty-two male and 52 female Wistar rats were submitted to a simulated air dive known to reliably induce about 63% DCS compression was performed at 100 kPa·min up to 1000 kPa absolute pressure before a 45-min long stay. Decompression was performed at 100 kPa·min with three decompression stops 5 min at 200 kPa, 5 min at 160 kPa, and 10 min at 130 kPa. Animals were observed for 1 h to detect DCS symptoms. Individuals without DCS were selected and bred to create a new generation, subsequently subjected to the same hyperbaric protocol. This procedure was repeated up to the third generation of rats.RESULTS:
As reported previously, this diving profile induced 67% of DCS, and 33% asymptomatic animals in the founding population. DCS/asymptomatic ratio was not initially different between sexes, although males were heavier than females. In three generations, the outcome of the dive significantly changed from 33% to 67% asymptomatic rats, for both sexes. Interestingly, survival in females increased sooner than in males.CONCLUSIONS:
This study offers evidence suggesting the inheritance of DCS resistance. Future research will focus on genetic and physiological comparisons between the initial strain and the new resistant population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Doença da Descompressão
/
Mergulho
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article