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Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening.
Brantley, Scott J; Cotten, Steven W; Lamson, David R; Smith, Ginger R; Liu, Rihe; Williams, Kevin P.
Afiliação
  • Brantley SJ; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Cotten SW; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Lamson DR; Biomanufacturing Research Institute and Technology Enterprise, Durham, NC 27707, USA.
  • Smith GR; Biomanufacturing Research Institute and Technology Enterprise, Durham, NC 27707, USA.
  • Liu R; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: rihe_liu@unc.edu.
  • Williams KP; Biomanufacturing Research Institute and Technology Enterprise, Durham, NC 27707, USA; Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC 27707, USA. Electronic address: kpwilliams@nccu.edu.
Biochem Biophys Res Commun ; 491(3): 773-779, 2017 09 23.
Article em En | MEDLINE | ID: mdl-28733033
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Caenorhabditis elegans / Avaliação Pré-Clínica de Medicamentos / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Inibidores de Caspase Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Caenorhabditis elegans / Avaliação Pré-Clínica de Medicamentos / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Inibidores de Caspase Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article