Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPAR&#945;/Î³ dual agonist, protects against ischemia-induced brain damage in mice by inhibiting inflammatory responses.

Li, Ying; Xu, Lanxi; Zeng, Kaiyue; Xu, Zhentian; Suo, Daqin; Peng, Lu; Ren, Tong; Sun, Zhiheng; Yang, Wushuang; Jin, Xin; Yang, Lichao

Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/Î³ dual agonist, protects against ischemia-induced brain damage in mice by inhibiting inflammatory responses.

Li, Ying; Xu, Lanxi; Zeng, Kaiyue; Xu, Zhentian; Suo, Daqin; Peng, Lu; Ren, Tong; Sun, Zhiheng; Yang, Wushuang; Jin, Xin; Yang, Lichao.

Afiliação

Li Y; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China; Department of Pharmacy, Xiamen Medical College, Xiamen, China.
Xu L; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China.
Zeng K; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China.
Xu Z; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China.
Suo D; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China.
Peng L; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China.
Ren T; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China.
Sun Z; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China.
Yang W; Department of Neurosurgery, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China.
Jin X; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China. Electronic address: xinjin@xmu.edu.cn.
Yang L; Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen, China. Electronic address: yanglc116@xmu.edu.cn.

Brain Behav Immun ; 66: 289-301, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28736035

Assuntos

Isquemia Encefálica/prevenção & controle; Encefalite/prevenção & controle; Fármacos Neuroprotetores/administração & dosagem; PPAR alfa/agonistas; PPAR gama/agonistas; Ácidos Sulfônicos/administração & dosagem; Animais; Barreira Hematoencefálica/metabolismo; Encéfalo/metabolismo; Isquemia Encefálica/complicações; Isquemia Encefálica/metabolismo; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Encefalite/complicações; Lipopolissacarídeos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Camundongos; Microglia/efeitos dos fármacos; NF-kappa B/metabolismo; PPAR alfa/metabolismo; PPAR gama/metabolismo; Ratos Sprague-Dawley; Fator de Transcrição STAT3/metabolismo

Palavras-chave

Activated microglia/macrophages; Focal cerebral ischemia; Inflammation; Mice; Propane-2-sulfonic acid octadec-9-enyl-amide

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Sulfônicos / Isquemia Encefálica / Fármacos Neuroprotetores / PPAR alfa / PPAR gama / Encefalite Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google