[Protective effects of glycyrrhizic acid against lupus nephritis in MRL/lpr mice].
Nan Fang Yi Ke Da Xue Xue Bao
; 37(7): 957-961, 2017 Jul 20.
Article
em Zh
| MEDLINE
| ID: mdl-28736376
OBJECTIVE: To investigate protective effect of glycyrrhizic acid (GA) against lupus nephritis in MRL/lpr mice and explore its underlying mechanisms. METHODS: Forty MRL/lpr mice were randomized equally into blank control group, dexamethasone (1.5 mg/kg) group, GA (20 mg/kg) group, and GA (40 mg/kg) group with corresponding treatments for 7 days, with 10 wild-type mice as the control group. Serum levels of uric acid and creatinine and inflammatory cytokines in the serum and kidney were tested after the treatments using enzyme-linked immunosorbent assays (ELISA). The pathological changes in the kidneys were detected using HE staining, and the protein expressions of NLRP3, ASC, caspase-1, IL-1ß, p-NF-κB, NF-κB, p-IκBα, and IκBα were detected with Western blotting. RESULTS: GA obviously decreased serum levels of uric acid and creatinine, decreased inflammatory cytokines in the serum and kidney, ameliorated renal pathologies and inhibited the expressions of NLRP3, ASC, caspase-1, IL-1ß, p-NF-κB, and p-IκBα proteins in MRL/lpr mice. CONCLUSION: GA has protective effects against lupus nephritis in MRL/lpr mice.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article