Here, There, and Anywhere? Arguments for and against the Physical Plasma Cell Survival Niche.
J Immunol
; 199(3): 839-845, 2017 08 01.
Article
em En
| MEDLINE
| ID: mdl-28739594
ABSTRACT
To maintain Ab titers, individual plasma cells must survive for extended periods, perhaps even for the life of the host. Although it is clear that plasma cell survival requires cell extrinsic signals, the nature and source of these signals remains open for debate. It is commonly postulated that plasma cells only gain access to these signals within specialized regulatory microenvironments, or niches, in the bone marrow or in the gut. In this review we discuss current concepts and information surrounding plasma cell survival niches, and consider two opposing models to explain long-term serologic immunity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Medula Óssea
/
Sobrevivência Celular
/
Microambiente Celular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article