Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy.

Refos, Jeannine M; Vonk, Alieke G; Ten Kate, Marian T; Eadie, Kimberly; Verbrugh, Henri A; Bakker-Woudenberg, Irma A J M; van de Sande, Wendy W J

Refos, Jeannine M; Vonk, Alieke G; Ten Kate, Marian T; Eadie, Kimberly; Verbrugh, Henri A; Bakker-Woudenberg, Irma A J M; van de Sande, Wendy W J.

Afiliação

Refos JM; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Vonk AG; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Ten Kate MT; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Eadie K; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Verbrugh HA; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Bakker-Woudenberg IAJM; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
van de Sande WWJ; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.

PLoS One ; 12(7): e0180961, 2017.

Article em En | MEDLINE | ID: mdl-28742113

Assuntos

Benzoquinonas/administração & dosagem; Equinocandinas/administração & dosagem; Aspergilose Pulmonar Invasiva/tratamento farmacológico; Lactamas Macrocíclicas/administração & dosagem; Lipopeptídeos/administração & dosagem; Animais; Antifúngicos/administração & dosagem; Aspergillus fumigatus/efeitos dos fármacos; Benzoquinonas/toxicidade; Caspofungina; Modelos Animais de Doenças; Sinergismo Farmacológico; Quimioterapia Combinada; Feminino; Humanos; Aspergilose Pulmonar Invasiva/complicações; Aspergilose Pulmonar Invasiva/microbiologia; Lactamas Macrocíclicas/toxicidade; Testes de Sensibilidade Microbiana; Neutropenia/complicações; Ratos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzoquinonas / Lactamas Macrocíclicas / Equinocandinas / Aspergilose Pulmonar Invasiva / Lipopeptídeos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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