Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney.

Radón, Victoria; Czesla, Maire; Reichelt, Julia; Fehlert, Julia; Hammel, Anna; Rosendahl, Alva; Knop, Jan-Hendrik; Wiech, Thorsten; Wenzel, Ulrich O; Sachs, Marlies; Reinicke, Anna T; Stahl, Rolf A K; Meyer-Schwesinger, Catherine

Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney.

Radón, Victoria; Czesla, Maire; Reichelt, Julia; Fehlert, Julia; Hammel, Anna; Rosendahl, Alva; Knop, Jan-Hendrik; Wiech, Thorsten; Wenzel, Ulrich O; Sachs, Marlies; Reinicke, Anna T; Stahl, Rolf A K; Meyer-Schwesinger, Catherine.

Afiliação

Radón V; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Czesla M; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Reichelt J; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Fehlert J; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hammel A; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rosendahl A; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Knop JH; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Wiech T; Department of Pathology, Renal Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Wenzel UO; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sachs M; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Reinicke AT; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stahl RAK; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Meyer-Schwesinger C; Department of Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: c.meyer-schwesinger@uke.uni-hamburg.de.

Kidney Int ; 93(1): 110-127, 2018 01.

Article em En | MEDLINE | ID: mdl-28754552

Assuntos

Glomerulonefrite/enzimologia; Doenças do Complexo Imune/enzimologia; Podócitos/enzimologia; Complexo de Endopeptidases do Proteassoma/metabolismo; Ubiquitina Tiolesterase/metabolismo; Ubiquitina/metabolismo; Animais; Células Cultivadas; Modelos Animais de Doenças; Glomerulonefrite/genética; Glomerulonefrite/imunologia; Glomerulonefrite/patologia; Hipotensão/enzimologia; Hipotensão/genética; Doenças do Complexo Imune/genética; Doenças do Complexo Imune/imunologia; Doenças do Complexo Imune/patologia; Peptídeos e Proteínas de Sinalização Intracelular/deficiência; Peptídeos e Proteínas de Sinalização Intracelular/genética; Proteínas de Membrana/deficiência; Proteínas de Membrana/genética; Camundongos Knockout; Oxirredução; Podócitos/imunologia; Podócitos/patologia; Proteinúria/enzimologia; Proteinúria/genética; Proteólise; Ubiquitina Tiolesterase/deficiência; Ubiquitina Tiolesterase/genética; Ubiquitinação

Palavras-chave

immune-complex nephritis; proteasome abundance; ubiquitin-C-terminal hydrolase-L1; ubiquitin-proteasome system

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Complexo Imune / Ubiquitina / Ubiquitina Tiolesterase / Complexo de Endopeptidases do Proteassoma / Podócitos / Glomerulonefrite Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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