In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 61(10)2017 10.
Article
em En
| MEDLINE
| ID: mdl-28760892
ABSTRACT
Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA (rrl). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that may limit spread in clinical settings.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Ribossômicas
/
Inibidores da Síntese de Proteínas
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RNA Ribossômico 23S
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Farmacorresistência Bacteriana Múltipla
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Linezolida
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Mycobacterium tuberculosis
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article