Homeostatic enhancement of sensory transduction.
Proc Natl Acad Sci U S A
; 114(33): E6794-E6803, 2017 08 15.
Article
em En
| MEDLINE
| ID: mdl-28760949
ABSTRACT
Our sense of hearing boasts exquisite sensitivity, precise frequency discrimination, and a broad dynamic range. Experiments and modeling imply, however, that the auditory system achieves this performance for only a narrow range of parameter values. Small changes in these values could compromise hair cells' ability to detect stimuli. We propose that, rather than exerting tight control over parameters, the auditory system uses a homeostatic mechanism that increases the robustness of its operation to variation in parameter values. To slowly adjust the response to sinusoidal stimulation, the homeostatic mechanism feeds back a rectified version of the hair bundle's displacement to its adaptation process. When homeostasis is enforced, the range of parameter values for which the sensitivity, tuning sharpness, and dynamic range exceed specified thresholds can increase by more than an order of magnitude. Signatures in the hair cell's behavior provide a means to determine through experiment whether such a mechanism operates in the auditory system. Robustness of function through homeostasis may be ensured in any system through mechanisms similar to those that we describe here.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rana catesbeiana
/
Sáculo e Utrículo
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Mecanotransdução Celular
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Células Ciliadas Auditivas
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Homeostase
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article