The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186.

Wang, Yuan; Chen, Fuquan; Zhao, Man; Yang, Zhe; Li, Jiong; Zhang, Shuqin; Zhang, Weiying; Ye, Lihong; Zhang, Xiaodong

Wang, Yuan; Chen, Fuquan; Zhao, Man; Yang, Zhe; Li, Jiong; Zhang, Shuqin; Zhang, Weiying; Ye, Lihong; Zhang, Xiaodong.

Afiliação

Wang Y; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and.
Chen F; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and.
Zhao M; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and.
Yang Z; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and.
Li J; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and.
Zhang S; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and.
Zhang W; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and.
Ye L; the State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China yelihong@nankai.edu.cn.
Zhang X; From the State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China and zhangxd@nankai.edu.cn.

J Biol Chem ; 292(37): 15395-15407, 2017 09 15.

Article em En | MEDLINE | ID: mdl-28765279

Assuntos

Carcinogênese; Carcinoma Hepatocelular/metabolismo; Proteína HMGA2/agonistas; Hepatócitos/metabolismo; MicroRNAs/metabolismo; Modelos Biológicos; RNA Longo não Codificante/metabolismo; Regiões 3' não Traduzidas; Animais; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Proliferação de Células; Células HEK293; Proteína HMGA2/genética; Proteína HMGA2/metabolismo; Hepatócitos/patologia; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Masculino; Camundongos Nus; MicroRNAs/antagonistas & inibidores; Mutação; Transplante de Neoplasias; Interferência de RNA; RNA Longo não Codificante/antagonistas & inibidores; RNA Mensageiro/antagonistas & inibidores; RNA Mensageiro/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Carga Tumoral; Regulação para Cima

Palavras-chave

cell proliferation; hepatocellular carcinoma; high mobility group A2 (HMGA2); long noncoding RNA (long ncRNA, lncRNA); microRNA (miRNA); microRNA-186; oncogene; up-regulated in liver cancer (HULC)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Hepatócitos / Proteína HMGA2 / MicroRNAs / RNA Longo não Codificante / Carcinogênese / Modelos Biológicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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