Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and &#945;-Synuclein Transgenic Mice.

Leon, Julio; Moreno, Arturo J; Garay, Bayardo I; Chalkley, Robert J; Burlingame, Alma L; Wang, Dan; Dubal, Dena B

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice.

Leon, Julio; Moreno, Arturo J; Garay, Bayardo I; Chalkley, Robert J; Burlingame, Alma L; Wang, Dan; Dubal, Dena B.

Afiliação

Leon J; Department of Neurology, Biomedical Sciences Graduate Program, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Moreno AJ; Department of Neurology, Biomedical Sciences Graduate Program, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Garay BI; Department of Neurology, Biomedical Sciences Graduate Program, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Chalkley RJ; Department of Chemistry and Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Burlingame AL; Department of Chemistry and Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Wang D; Department of Neurology, Biomedical Sciences Graduate Program, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Dubal DB; Department of Neurology, Biomedical Sciences Graduate Program, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: dena.dubal@ucsf.edu.

Cell Rep ; 20(6): 1360-1371, 2017 08 08.

Article em En | MEDLINE | ID: mdl-28793260

Assuntos

Adaptação Psicológica; Encéfalo/efeitos dos fármacos; Cognição; Glucuronidase/farmacologia; Fragmentos de Peptídeos/farmacologia; alfa-Sinucleína/genética; Animais; Encéfalo/crescimento & desenvolvimento; Encéfalo/metabolismo; Encéfalo/fisiologia; Feminino; Glucuronidase/administração & dosagem; Glucuronidase/química; Proteínas Klotho; Locomoção; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Plasticidade Neuronal; Fragmentos de Peptídeos/administração & dosagem; Fragmentos de Peptídeos/química; Proteólise; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Receptores de N-Metil-D-Aspartato/metabolismo

Palavras-chave

Alzheimer disease; NMDA receptors; Parkinson disease; aging; brain; cognition; klotho; mice; motor function; α-synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Encéfalo / Adaptação Psicológica / Cognição / Alfa-Sinucleína / Glucuronidase Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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