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Transcription-Replication Conflicts: Orientation Matters.

Lin, Yea-Lih; Pasero, Philippe.
Cell ; 170(4): 603-604, 2017 08 10.
Artigo em Inglês | MEDLINE | ID: mdl-28802036
Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in bacteria and in human cells by promoting the formation of RNA-DNA hybrids known as R-loops.