Transcription-Replication Conflicts: Orientation Matters.
Cell
; 170(4): 603-604, 2017 08 10.
Article
em En
| MEDLINE
| ID: mdl-28802036
ABSTRACT
Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in bacteria and in human cells by promoting the formation of RNA-DNA hybrids known as R-loops.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Replicação do DNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article