Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3 cells by activation of oxidative stress and mitochondrial apoptosis.

Ding, Yan; Ren, Kai; Dong, Huanhuan; Song, Fei; Chen, Jing; Guo, Youtian; Liu, Yanshan; Tao, Weijie; Zhang, Yali

Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3 cells by activation of oxidative stress and mitochondrial apoptosis.

Ding, Yan; Ren, Kai; Dong, Huanhuan; Song, Fei; Chen, Jing; Guo, Youtian; Liu, Yanshan; Tao, Weijie; Zhang, Yali.

Afiliação

Ding Y; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Ren K; Department of Biochemistry and Molecular Biology, Xi'an Medical University, Xi'an, 710021, PR China; Department of Molecular Biotechnology, Molecular Biotechnology Center, University of Torino, Torino, Italy.
Dong H; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Song F; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Chen J; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Guo Y; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Liu Y; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Tao W; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Zhang Y; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China. Electronic address: yarlee@163.com.

Chem Biol Interact ; 275: 210-217, 2017 Sep 25.

Article em En | MEDLINE | ID: mdl-28811126

Assuntos

Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Diospyros/química; Flavonoides/farmacologia; Mitocôndrias/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Extratos Vegetais/farmacologia; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Citocromos c/metabolismo; Diospyros/metabolismo; Flavonoides/química; Flavonoides/isolamento & purificação; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Mitocôndrias/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Extratos Vegetais/química; Folhas de Planta/química; Folhas de Planta/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Regulação para Cima/efeitos dos fármacos; Proteína X Associada a bcl-2/metabolismo

Palavras-chave

Apoptosis; Cytotoxicity; Flavonoids; Oxidative stress; Persimmon leaves; Prostate cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Extratos Vegetais / Apoptose / Estresse Oxidativo / Diospyros / Proliferação de Células / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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