Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL.

McDowall, Jennifer S; Ntai, Ioanna; Honeychurch, Kevin C; Hart, John P; Colin, Philippe; Schneider, Bernard L; Brown, David R

McDowall, Jennifer S; Ntai, Ioanna; Honeychurch, Kevin C; Hart, John P; Colin, Philippe; Schneider, Bernard L; Brown, David R.

Afiliação

McDowall JS; Department of Biology and Biochemistry, University of Bath, Bath, UK.
Ntai I; Department of Biology and Biochemistry, University of Bath, Bath, UK.
Honeychurch KC; Department of Biological, Biomedical and Analytical Sciences, Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK.
Hart JP; Department of Biological, Biomedical and Analytical Sciences, Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK.
Colin P; Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.
Schneider BL; Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.
Brown DR; Department of Biology and Biochemistry, University of Bath, Bath, UK. Electronic address: bssdrb@bath.ac.uk.

Mol Cell Neurosci ; 85: 1-11, 2017 12.

Article em En | MEDLINE | ID: mdl-28811225

Assuntos

Encéfalo/metabolismo; Doença de Parkinson/metabolismo; alfa-Sinucleína/metabolismo; Animais; FMN Redutase/metabolismo; Feminino; Humanos; Masculino; Ratos; Ratos Sprague-Dawley

Palavras-chave

DOPAL; Ferrireductase; Iron; Neurotoxicity; Synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Encéfalo / Alfa-Sinucleína Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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