Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.

Xu, Zhe; Huo, Jia; Ding, Xin; Yang, Mu; Li, Lin; Dai, Jian; Hosoe, Kazunori; Kubo, Hiroshi; Mori, Masayuki; Higuchi, Keiichi; Sawashita, Jinko

Xu, Zhe; Huo, Jia; Ding, Xin; Yang, Mu; Li, Lin; Dai, Jian; Hosoe, Kazunori; Kubo, Hiroshi; Mori, Masayuki; Higuchi, Keiichi; Sawashita, Jinko.

Afiliação

Xu Z; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan. 346784565@qq.com.
Huo J; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.
Ding X; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.
Yang M; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.
Li L; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.
Dai J; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.
Hosoe K; Supplemental Nutrition Division, Pharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation, Osaka, 530-8288, Japan.
Kubo H; Supplemental Nutrition Division, Pharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation, Osaka, 530-8288, Japan.
Mori M; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.
Higuchi K; Department of Advanced Medicine for Heath Promotion, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto, 390-8621, Japan.
Sawashita J; Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.

Sci Rep ; 7(1): 8253, 2017 08 15.

Article em En | MEDLINE | ID: mdl-28811612

Assuntos

Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo; Metabolismo dos Lipídeos; Obesidade/metabolismo; Ubiquinona/análogos & derivados; Adipócitos/efeitos dos fármacos; Adipócitos/metabolismo; Tecido Adiposo Marrom/efeitos dos fármacos; Tecido Adiposo Marrom/metabolismo; Animais; Peso Corporal/efeitos dos fármacos; Sinalização do Cálcio/efeitos dos fármacos; Modelos Animais de Doenças; Regulação da Expressão Gênica/efeitos dos fármacos; Resistência à Insulina; Metabolismo dos Lipídeos/efeitos dos fármacos; Fígado/efeitos dos fármacos; Fígado/metabolismo; Síndrome Metabólica/tratamento farmacológico; Síndrome Metabólica/metabolismo; Camundongos; Obesidade/tratamento farmacológico; Obesidade/genética; Inibidores da Fosfodiesterase 4/farmacologia; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/genética; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo; Ubiquinona/metabolismo; Ubiquinona/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquinona / Metabolismo dos Lipídeos / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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