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Mechanism of intracellular allosteric ß2AR antagonist revealed by X-ray crystal structure.
Liu, Xiangyu; Ahn, Seungkirl; Kahsai, Alem W; Meng, Kai-Cheng; Latorraca, Naomi R; Pani, Biswaranjan; Venkatakrishnan, A J; Masoudi, Ali; Weis, William I; Dror, Ron O; Chen, Xin; Lefkowitz, Robert J; Kobilka, Brian K.
Afiliação
  • Liu X; Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Ahn S; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Kahsai AW; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Meng KC; Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, Jiangsu, China.
  • Latorraca NR; Department of Computer Science, Stanford University, Stanford, California 94305, USA.
  • Pani B; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, California 94305, USA.
  • Venkatakrishnan AJ; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Masoudi A; Department of Computer Science, Stanford University, Stanford, California 94305, USA.
  • Weis WI; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, California 94305, USA.
  • Dror RO; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, USA.
  • Chen X; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Lefkowitz RJ; Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Kobilka BK; Department of Computer Science, Stanford University, Stanford, California 94305, USA.
Nature ; 548(7668): 480-484, 2017 08 24.
Article em En | MEDLINE | ID: mdl-28813418
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta 2 / Espaço Intracelular / Dipeptídeos / Antagonistas de Receptores Adrenérgicos beta 2 Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta 2 / Espaço Intracelular / Dipeptídeos / Antagonistas de Receptores Adrenérgicos beta 2 Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article