Simultaneous inhibition of IGF1R and EGFR enhances the efficacy of standard treatment for colorectal cancer by the impairment of DNA repair and the induction of cell death.

Oberthür, Rabea; Seemann, Henning; Gehrig, Julia; Rave-Fränk, Margret; Bremmer, Felix; Halpape, Rovena; Conradi, Lena-Christin; Scharf, Jens-Gerd; Burfeind, Peter; Kaulfuß, Silke

Oberthür, Rabea; Seemann, Henning; Gehrig, Julia; Rave-Fränk, Margret; Bremmer, Felix; Halpape, Rovena; Conradi, Lena-Christin; Scharf, Jens-Gerd; Burfeind, Peter; Kaulfuß, Silke.

Afiliação

Oberthür R; Institute of Human Genetics, University Medical Centre Göttingen, Germany.
Seemann H; Institute of Human Genetics, University Medical Centre Göttingen, Germany.
Gehrig J; Institute of Human Genetics, University Medical Centre Göttingen, Germany.
Rave-Fränk M; Department of Radiotherapy and Radio Oncology, University Medical Centre Göttingen, Germany.
Bremmer F; Institute of Pathology, University Medical Centre Göttingen, Germany.
Halpape R; Institute of Human Genetics, University Medical Centre Göttingen, Germany.
Conradi LC; Department of General, Visceral and Paediatric Surgery, University Medical Centre Göttingen, Germany.
Scharf JG; 2nd Department of Internal Medicine, HELIOS Hospital Erfurt, Germany.
Burfeind P; Institute of Human Genetics, University Medical Centre Göttingen, Germany.
Kaulfuß S; Institute of Human Genetics, University Medical Centre Göttingen, Germany. Electronic address: silke@kaulfuss.eu.

Cancer Lett ; 407: 93-105, 2017 10 28.

Article em En | MEDLINE | ID: mdl-28823963

Assuntos

Antineoplásicos/uso terapêutico; Neoplasias Colorretais/tratamento farmacológico; Reparo do DNA/efeitos dos fármacos; Receptores ErbB/antagonistas & inibidores; Terapia de Alvo Molecular/métodos; Inibidores de Proteínas Quinases/uso terapêutico; Receptor IGF Tipo 1/antagonistas & inibidores; Idoso; Idoso de 80 Anos ou mais; Animais; Antineoplásicos/farmacologia; Caspase 3/metabolismo; Morte Celular/efeitos dos fármacos; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Modelos Animais de Doenças; Receptores ErbB/metabolismo; Feminino; Humanos; Masculino; Camundongos; Pessoa de Meia-Idade; Inibidores de Proteínas Quinases/farmacologia; Receptor IGF Tipo 1/metabolismo; Células Tumorais Cultivadas

Palavras-chave

Apoptosis; DNA damage; EGFR; Heterodimerisation; IGF1R; Radiochemotherapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Receptor IGF Tipo 1 / Inibidores de Proteínas Quinases / Reparo do DNA / Terapia de Alvo Molecular / Receptores ErbB / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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