The acute toxic effects of silver nanoparticles on myocardial transmembrane potential, I<sub>Na</sub> and I<sub>K1</sub> channels and heart rhythm in mice.

Lin, Cai-Xia; Yang, Su-Yu; Gu, Jing-Li; Meng, Jie; Xu, Hai-Yan; Cao, Ji-Min

The acute toxic effects of silver nanoparticles on myocardial transmembrane potential, I_Na and I_K1 channels and heart rhythm in mice.

Lin, Cai-Xia; Yang, Su-Yu; Gu, Jing-Li; Meng, Jie; Xu, Hai-Yan; Cao, Ji-Min.

Afiliação

Lin CX; a Department of Physiology , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College , Beijing , China.
Yang SY; a Department of Physiology , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College , Beijing , China.
Gu JL; a Department of Physiology , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College , Beijing , China.
Meng J; b Department of Biomedical Engineering , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College , Beijing , China.
Xu HY; b Department of Biomedical Engineering , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College , Beijing , China.
Cao JM; a Department of Physiology , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College , Beijing , China.

Nanotoxicology ; 11(6): 827-837, 2017 Aug.

Article em En | MEDLINE | ID: mdl-28830271

Assuntos

Potenciais da Membrana/efeitos dos fármacos; Nanopartículas Metálicas/toxicidade; Miócitos Cardíacos/efeitos dos fármacos; Canais de Potássio Corretores do Fluxo de Internalização/metabolismo; Prata/toxicidade; Canais de Sódio/metabolismo; Animais; Células Cultivadas; Relação Dose-Resposta a Droga; Endocitose/efeitos dos fármacos; Frequência Cardíaca/efeitos dos fármacos; Hidrogéis/toxicidade; L-Lactato Desidrogenase; Camundongos; Camundongos Endogâmicos C57BL; Técnicas de Patch-Clamp; Compostos de Prata/toxicidade; Fatores de Tempo

Palavras-chave

Silver nanoparticle; arrhythmia; cardiac electrophysiology; ion channel; nanobiosafety

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Canais de Sódio / Canais de Potássio Corretores do Fluxo de Internalização / Miócitos Cardíacos / Nanopartículas Metálicas / Potenciais da Membrana Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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