Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV.
AIDS
; 31(16): 2253-2259, 2017 10 23.
Article
em En
| MEDLINE
| ID: mdl-28832410
ABSTRACT
OBJECTIVE:
Tesamorelin reduces visceral adipose tissue (VAT) in HIV. We investigated whether reductions in VAT with tesamorelin are associated with changes in alanine aminotransferase (ALT) and aspartate aminotransferase (AST). DESIGN ANDMETHODS:
We utilized data from two multicenter Phase III trials of tesamorelin among 806 HIV-infected patients with abdominal obesity. These studies showed that the majority of patients treated with tesamorelin are 'responders', defined a priori by the Food and Drug Administration as achieving at least 8% reduction in VAT. In the current analysis, we sought to examine the impact of VAT reduction on ALT and AST among patients participating in the Phase III trials with baseline elevated ALT or AST. Within this group, we compared changes in ALT and AST in VAT responders vs. nonresponders after 26 weeks of treatment, and then assessed the effects of drug discontinuation on these endpoints over a subsequent 26-week period.RESULTS:
At baseline, VAT was positively associated with ALT (Pâ=â0.01). In study participants assigned to tesamorelin with baseline ALT or AST more than 30âU/l, VAT responders experienced greater reductions in ALT (-8.9â±â22.6 vs. 1.4â±â34.7âU/l, Pâ=â0.004) and AST (-3.8â±â12.9 vs. 0.4â±â22.4âU/l, Pâ=â0.04) compared with nonresponders over 26 weeks. This improvement among VAT responders persisted over 52 weeks even in those switched to placebo despite a partial reaccumulation of VAT.CONCLUSION:
A clinically significant VAT reduction with tesamorelin was associated with improved liver enzymes among HIV-infected patients with abdominal obesity and elevated baseline transaminases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspartato Aminotransferases
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Infecções por HIV
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Hormônio Liberador de Hormônio do Crescimento
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Fármacos Antiobesidade
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Alanina Transaminase
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Fígado Gorduroso
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Obesidade
Tipo de estudo:
Clinical_trials
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article