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Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.
Narayanam, Maruthi Kumar; Ma, Gaoyuan; Champagne, Pier Alexandre; Houk, Kendall N; Murphy, Jennifer M.
Afiliação
  • Narayanam MK; Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Ma G; Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Champagne PA; Department of Chemistry and Biochemistry, and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Houk KN; Department of Chemistry and Biochemistry, and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Murphy JM; Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Angew Chem Int Ed Engl ; 56(42): 13006-13010, 2017 10 09.
Article em En | MEDLINE | ID: mdl-28834065
A practical method for radiofluorination of anilines with [18 F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18 F-labeling to prepare [18 F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18 F-labeled neuropeptide.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sidnonas / Compostos Radiofarmacêuticos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sidnonas / Compostos Radiofarmacêuticos Idioma: En Ano de publicação: 2017 Tipo de documento: Article