Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma.
Pediatr Blood Cancer
; 65(1)2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-28843052
ABSTRACT
We report the case of a 14-year-old male with metastatic alveolar rhabdomyosarcoma, presenting with hypercalcaemia (3.89 mmol/l) and elevated parathyroid hormone (PTH) level (10.2 pmol/l). Imaging demonstrated extensive bony lytic damage, with "floating teeth" in the mandible. Normalisation of calcium levels and bony reformation of the mandible occurred following chemotherapy; PTH levels decreased initially but remained above normal levels. Imaging did not demonstrate any evidence of parathyroid abnormality. Tumour ectopic PTH secretion is a very rare cause of hypercalcaemia of malignancy in children. Hypercalcaemia with an elevated PTH, in the absence of parathyroid-related cause, should prompt investigation for underlying malignancy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
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Regulação Neoplásica da Expressão Gênica
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Perda do Osso Alveolar
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Rabdomiossarcoma Alveolar
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Hipercalcemia
Limite:
Adolescent
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article