Growth arrest and DNA damage-inducible 45&#945; protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Tanaka, Naoki; Takahashi, Shogo; Hu, Xiao; Lu, Yu; Fujimori, Naoyuki; Golla, Srujana; Fang, Zhong-Ze; Aoyama, Toshifumi; Krausz, Kristopher W; Gonzalez, Frank J

Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Tanaka, Naoki; Takahashi, Shogo; Hu, Xiao; Lu, Yu; Fujimori, Naoyuki; Golla, Srujana; Fang, Zhong-Ze; Aoyama, Toshifumi; Krausz, Kristopher W; Gonzalez, Frank J.

Afiliação

Tanaka N; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Research Center for Agricultural Food Industry, Shinshu U
Takahashi S; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Hu X; Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Lu Y; Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Fujimori N; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan.
Golla S; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Fang ZZ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Department of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, China.
Aoyama T; Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Krausz KW; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Gonzalez FJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: gonzalef@mail.nih.gov.

Biochim Biophys Acta Mol Basis Dis ; 1863(12): 3170-3182, 2017 12.

Article em En | MEDLINE | ID: mdl-28844958

Assuntos

Proteínas de Ciclo Celular/deficiência; Deficiência de Colina/metabolismo; Glicerofosfolipídeos/metabolismo; Metionina/deficiência; Hepatopatia Gordurosa não Alcoólica/prevenção & controle; Proteínas Nucleares/deficiência; Animais; Proteínas de Ciclo Celular/metabolismo; Dieta; Estresse do Retículo Endoplasmático/fisiologia; Proteínas de Transporte de Ácido Graxo/metabolismo; Proteínas de Ligação a Ácido Graxo/metabolismo; Ácidos Graxos/metabolismo; Hepatócitos/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Hepatopatia Gordurosa não Alcoólica/metabolismo; Hepatopatia Gordurosa não Alcoólica/patologia; Proteínas Nucleares/metabolismo; Fosfatidato Fosfatase/metabolismo; Fosfolipase D/metabolismo; RNA Mensageiro/metabolismo; Transferases (Outros Grupos de Fosfato Substituídos)/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Triglicerídeos/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Burned-out NASH; ER stress; Glycerophospholipid metabolism; Lipidomics; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Deficiência de Colina / Proteínas de Ciclo Celular / Glicerofosfolipídeos / Hepatopatia Gordurosa não Alcoólica / Metionina Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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