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A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.
Schmidt, Jurema; Rotter, Marco; Weiser, Tim; Wittmann, Sandra; Weizel, Lilia; Kaiser, Astrid; Heering, Jan; Goebel, Tamara; Angioni, Carlo; Wurglics, Mario; Paulke, Alexander; Geisslinger, Gerd; Kahnt, Astrid; Steinhilber, Dieter; Proschak, Ewgenij; Merk, Daniel.
Afiliação
  • Schmidt J; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Rotter M; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Weiser T; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Wittmann S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Weizel L; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Kaiser A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Heering J; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME , Theodor-Stern-Kai 7, D-60596 Frankfurt am Main, Germany.
  • Goebel T; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Angioni C; Institute of Clinical Pharmacology, Goethe University Frankfurt , Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.
  • Wurglics M; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Paulke A; Department of Forensic Toxicology, Institute of Forensic Medicine, Goethe University Frankfurt , Kennedyallee 104, D-60596 Frankfurt, Germany.
  • Geisslinger G; Institute of Clinical Pharmacology, Goethe University Frankfurt , Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.
  • Kahnt A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Proschak E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
  • Merk D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt , Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
J Med Chem ; 60(18): 7703-7724, 2017 09 28.
Article em En | MEDLINE | ID: mdl-28845983
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Citoplasmáticos e Nucleares / Inibidores Enzimáticos / Epóxido Hidrolases / Hepatopatia Gordurosa não Alcoólica / Anti-Inflamatórios Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Citoplasmáticos e Nucleares / Inibidores Enzimáticos / Epóxido Hidrolases / Hepatopatia Gordurosa não Alcoólica / Anti-Inflamatórios Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article