Chronic urticaria and the metabolic syndrome: a cross-sectional community-based study of 11 261 patients.
J Eur Acad Dermatol Venereol
; 32(2): 276-281, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-28846167
ABSTRACT
BACKGROUND:
Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low-grade, inflammatory process.OBJECTIVE:
To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database.METHODS:
A cross-sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected.RESULTS:
The study included 11 261 patients with CU and 67 216 controls. In a univariate analysis, CU was significantly associated with higher body mass index (BMI) and a higher prevalence of obesity, diabetes, hyperlipidaemia, hypertension, metabolic syndrome, chronic renal failure and gout. Multivariate analysis demonstrated a significant association between CU and metabolic syndrome (OR = 1.12, 95% CI 1.1-1.2, P < 0.001) and its components - obesity (OR = 1.2, 95% CI 1.1-1.3, P < 0.001), diabetes (OR = 1.08, 95% CI 1.01-1.15, P = 0.001), hyperlipidaemia (OR = 1.2, 95% CI 1.1-1.2, P < 0.001) and hypertension (OR = 1.1, 95% CI 1.1-1.2, P < 0.001).CONCLUSIONS:
CU patients may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Urticária
/
Síndrome Metabólica
/
Diabetes Mellitus
/
Hiperlipidemias
/
Hipertensão
/
Obesidade
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article