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Insulin glargine and its two active metabolites: A sensitive (16pM) and robust simultaneous hybrid assay coupling immunoaffinity purification with LC-MS/MS to support biosimilar clinical studies.
Xu, Yang; Sun, Li; Anderson, Melanie; Bélanger, Philippe; Trinh, Vincent; Lavallée, Patricia; Kantesaria, Bhavna; Marcoux, Marie-Josée; Breidinger, Sheila; Bateman, Kevin P; Goykhman, Dina; Woolf, Eric J.
Afiliação
  • Xu Y; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA. Electronic address: yang_xu@merck.com.
  • Sun L; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA.
  • Anderson M; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA.
  • Bélanger P; inVentiv Health Clinique, 2500 Einstein, Quebec G1P 0A2, Canada.
  • Trinh V; inVentiv Health Clinique, 2500 Einstein, Quebec G1P 0A2, Canada.
  • Lavallée P; inVentiv Health Clinique, 2500 Einstein, Quebec G1P 0A2, Canada.
  • Kantesaria B; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA.
  • Marcoux MJ; inVentiv Health Clinique, 2500 Einstein, Quebec G1P 0A2, Canada.
  • Breidinger S; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA.
  • Bateman KP; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA.
  • Goykhman D; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA.
  • Woolf EJ; MRL, Department of PPDM, Regulated Bioanalysis, 770 Sumneytown Pike, WP75B-300, West Point, PA 19486, USA.
J Chromatogr B Analyt Technol Biomed Life Sci ; 1063: 50-59, 2017 Sep 15.
Article em En | MEDLINE | ID: mdl-28846865
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Espectrometria de Massas em Tandem / Insulina Glargina Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Espectrometria de Massas em Tandem / Insulina Glargina Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article