Nitazoxanide is active against Mycobacterium leprae.
PLoS One
; 12(8): e0184107, 2017.
Article
em En
| MEDLINE
| ID: mdl-28850614
ABSTRACT
Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Hanseníase
/
Antibacterianos
/
Mycobacterium leprae
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article