Low molecular weight hydrogels derived from urea based-bolaamphiphiles as new injectable biomaterials.
Biomaterials
; 145: 72-80, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28850933
ABSTRACT
There is a critical need for soft materials in the field of regenerative medicine and tissue engineering. However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications. Here we use a bottom-up approach for synthesizing supramolecular gels to generate novel biomaterial candidates. We evaluated the low molecular weight gels candidates in vivo and identified one urea-containing molecule, compound 16, that avoid foreign body reactions in mice. The self-assembly of bolaamphiphiles creates a unique hydrogel supramolecular structures featuring fast gelation kinetics, high elastic moduli, thixotropic, and thermal reversibility properties. This soft material, which inhibits recognition by macrophages and fibrous deposition, exhibits long-term stability after in vivo injection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridonas
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Ureia
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Materiais Biocompatíveis
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Hidrogéis
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Furanos
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Injeções
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article