Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers.

Stueve, Theresa Ryan; Li, Wen-Qing; Shi, Jianxin; Marconett, Crystal N; Zhang, Tongwu; Yang, Chenchen; Mullen, Daniel; Yan, Chunli; Wheeler, William; Hua, Xing; Zhou, Beiyun; Borok, Zea; Caporaso, Neil E; Pesatori, Angela C; Duan, Jubao; Laird-Offringa, Ite A; Landi, Maria Teresa

Stueve, Theresa Ryan; Li, Wen-Qing; Shi, Jianxin; Marconett, Crystal N; Zhang, Tongwu; Yang, Chenchen; Mullen, Daniel; Yan, Chunli; Wheeler, William; Hua, Xing; Zhou, Beiyun; Borok, Zea; Caporaso, Neil E; Pesatori, Angela C; Duan, Jubao; Laird-Offringa, Ite A; Landi, Maria Teresa.

Afiliação

Stueve TR; Department of Preventive Medicine.
Li WQ; USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Shi J; Division of Cancer Epidemiology and Genetics, NCI, National Institute of Health, Bethesda, MD 20852, USA.
Marconett CN; Department of Dermatology, Warren Alpert Medical School.
Zhang T; Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA.
Yang C; Division of Cancer Epidemiology and Genetics, NCI, National Institute of Health, Bethesda, MD 20852, USA.
Mullen D; USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Yan C; Department of Surgery.
Wheeler W; Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Hua X; Division of Cancer Epidemiology and Genetics, NCI, National Institute of Health, Bethesda, MD 20852, USA.
Zhou B; USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Borok Z; Department of Surgery.
Caporaso NE; Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Pesatori AC; USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Duan J; Department of Surgery.
Laird-Offringa IA; Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Landi MT; USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

Hum Mol Genet ; 26(15): 3014-3027, 2017 08 01.

Article em En | MEDLINE | ID: mdl-28854564

Assuntos

Ilhas de CpG/genética; Neoplasias Pulmonares/genética; Fumar/efeitos adversos; Células A549/metabolismo; Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Biomarcadores Tumorais/sangue; Citocromo P-450 CYP1B1/genética; Citocromo P-450 CYP1B1/metabolismo; Metilação de DNA/genética; Elementos Facilitadores Genéticos/genética; Epigênese Genética/genética; Epigenômica/métodos; Estudo de Associação Genômica Ampla; Humanos; Pulmão/efeitos dos fármacos; Pulmão/metabolismo; Sequências Reguladoras de Ácido Nucleico/genética; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Fumar/genética; Nicotiana

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fumar / Ilhas de CpG / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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