High-Level Resistance to Colistin Mediated by Various Mutations in the crrB Gene among Carbapenemase-Producing Klebsiella pneumoniae.
Antimicrob Agents Chemother
; 61(11)2017 11.
Article
em En
| MEDLINE
| ID: mdl-28874377
ABSTRACT
Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the susceptibility to colistin in all cases, confirming the involvement of the identified substitutions in the resistance phenotype.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Colistina
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Farmacorresistência Bacteriana
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Klebsiella pneumoniae
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Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article